Strain Data Sheet
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Data update: Jun 21, 2017
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RBRC No. RBRC01420  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6;129P2-Irf7<tm1Ttg>/TtgRbrc  
Former Common name IRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J  
H-2 Haplotype No Data  
ES cell line E14.1 [129P2/OlaHsd]  
Donor strain 129P2/OlaHsd via E14.1 ES cell line  
Background strain C57BL/6J  
Appearance
 1 Appearance black  
Genotype a/a  
Strain development Developed by Kenya Honda and Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo in 2001. The knockout construct was electroporated into E14 ES cells derived from 129P2/OlaHsd. C57BL/6 semicongenic strain.  
Strain description IRF7 knockout mice. Exon 2 and 3 of Irf7 gene were replaced with a PGK-beta-geo cassette. Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level.  
Colony maintenance Homozygote x Homozygote  
Health Report
Gene Details
Promoter No Data  
 1 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
 2 Symbol Irf7  
Symbol name interferon regulatory factor 7  
Chromosome 7  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 7  
Common name No Data  
Symbol description E. coli beta galactosidase  
References Nature. 2005 Apr 7;434(7034):772-7. Epub 2005 Mar 30.  

Research applications Fluorescent Proteins/lacZ System  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.  
Additional information
 1 Mouse of the Month May 2005
Genetic Background  
 2 Taniguchi Lab HP  
 3 Genotyping protocol <PCR>  
Depositor Taniguchi, Tadatsugu (The University of Tokyo, Graduate School of Medicine)  Taniguchi, Tadatsugu 
Strain Status /
Availability
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