Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Nov 22, 2017
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RBRC No. RBRC02149  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Ctnnbip1<tm1Taki>  
Former Common name ICAT Knock-out mouse  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Akiyama at Institute for Molecular and Cellular Bioscviences, University of Tokyo in 2001.  
Strain description ICAT, Inhibitor of beta-catenin and Tcell factor is an 81 amino acid protein that interferes with the interaction between beta-catenin and TCF. The ICAT gene ubiquitously expressed in embryo, and brain, heart, liver and skeletal muscle in adult of mouse. ICAT homozygous mutant mice show malformation of the forebrain and craniofacial bones and lack kidney, and dead within 1 day after birth.  
Colony maintenance Heterozygote x C57BL/6 [C57BL/6NJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ctnnbip1  
Symbol name catenin beta interacting protein 1  
Chromosome 4  
Common name 1110008O09Rik, 2310001I19Rik, Catnbip1, ICAT  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 4  
Common name neo; neomycin;  
Symbol description No Data  
References Proc Natl Acad Sci U S A 2004 May 25;101(21):8017-21. Epub 2004 May 17.  
Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling.
Research applications Developmental Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 101, 8017-8021 (2004).
The RECIPIENT of BIOLOGICAL RESOURCE shall inform the DEPOSITOR about the research project using the BIOLOGICAL RESOURCE, and agrees to include the DEPOSITOR as a co-author in any publications resulted by the used of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. After the two years' period the RECIPIENT shall acknowledge to the DEPOSITOR in any publications resulted by the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Lab HP (Japanese)  
 2 Genetic Background  
 3 Genotyping protocol <PCR>  
Depositor Akiyama, Tetsu (The University of Tokyo)  Akiyama, Tetsu 
Strain Status /
Availability
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