|
RBRC No. |
RBRC02189
|
|
Type |
Transgene |
 |
|
Species |
Mus musculus |
|
Strain name |
C57BL/6Cr-Tg(Pcdh21-cre)BYoko |
|
Former Common name |
Pcdh21-nCre, C57BL/6 |
|
H-2 Haplotype |
No Data |
|
Background strain |
C57BL/6 |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
a/a B/B C/C |
|
Strain development |
Developed by Dr. Mineto Yokoi Kyoto University Guraduate School of Medicine nin 2004. |
|
Strain description |
This transgenic mice express the cre recombinase gene under the control of the Pcdh21 gene promoter. This can be used to make an conditional knock-out by crossing with the other genetically-engineered mice that have floxed genes. The expression of cre recombinase was observed in the mitral/tufted cells that are projection neurons in the olfactory bulb. |
|
Colony maintenance |
Backcross to C57BL/6 (Hemizygote x C57BL/6CrSlc) |
|
Health Report |
|
|
Gene Details |
|
Promoter |
Pcdh21 promoter |
| 1 |
Symbol |
tTA |
| Symbol name |
tetracycline-transactivator gene |
| Chromosome |
UN |
| Common name |
E. coli tet repressor (TetR), herpes simplex virus (HSV)VP16 activation domain |
| Symbol description |
No Data |
| 2 |
Symbol |
cre |
| Symbol name |
Phage P1 Cre recombinase |
| Chromosome |
UN |
| Common name |
No Data |
| Symbol description |
No Data |
|
References |
Genesis 2005 Sep;43(1):12-6. Transgenic expression of Cre recombinase in mitral/tufted cells of the olfactory bulb. |
|
Research applications |
Cre/loxP system,
Neurobiology Research,
Tet system |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genesis, 43, 12-16 (2005). |
|
Additional information |
|
1 |
Genetic Background |
|
2 |
Genotyping protocol <PCR> |
|
Depositor |
Yokoi, Mineto (Graduate School of Medicine, Kyoto University)  |
|
Strain Status /
Availability
(Expected delivery) |
|
