|
RBRC No. |
RBRC02323
|
|
Type |
Targeted Mutation |
 |
|
Species |
Mus musculus |
|
Strain name |
B6JNrs.129S6-Atm<tm1Awb>/NrsFnt |
|
Former Common name |
B6-Atm knock-out mice |
|
H-2 Haplotype |
No Data |
|
Background strain |
No Data |
|
Appearance |
| 1 |
Appearance |
black |
| Genotype |
a/a B/B C/C |
|
Strain development |
The targeted alle was developed by Dr. A. Wynshow-Boris, NHI. The mutant mice were introduced into NRS in 1997, and then generated the Atm KO mice of C57BL/6 background by backcrossing to C57BL/6JNrs for 16 times. |
|
Strain description |
Atm, ataxia telangiectasia mutated homolog (human) gene knockout mice. Homozygous mutant mice disrupted Atm gene exhibit growth retardatuin, neurologic dysfunction, infertility, defects in T lymphocyte maturation. |
|
Colony maintenance |
Sibling Mating (Heterozygote x Wild-type) |
|
Health Report |
|
|
Gene Details |
|
Promoter |
No Data |
| 1 |
Symbol |
Atm |
| Symbol name |
ataxia telangiectasia mutated homolog (human) |
| Chromosome |
9 |
| Common name |
C030026E19Rik |
| Symbol description |
No Data |
|
Promoter |
human phosphoglycerate kinase promoter (PGK promoter) |
| 2 |
Symbol |
neo |
| Symbol name |
neomycin resistance gene (E. coli) |
| Chromosome |
9 |
| Common name |
neo; neomycin; |
| Symbol description |
No Data |
|
References |
Cell. 1996 Jul 12;86(1):159-71. Atm-deficient mice: a paradigm of ataxia telangiectasia. |
|
Research applications |
Cancer Research,
Immunology and Inflammation Research |
|
Specific Term and Conditions |
The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell. 89, 159-171 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowlidgement to Dr. Kouichi Tatsumi is requested. |
|
Additional information |
|
1 |
Genetic Background |
|
2 |
Genotyping protocol <PCR> |
|
Depositor |
Tsuji, Hideo (National Institute of Radiological Sciences)  |
|
Strain Status /
Availability
(Expected delivery) |
|
