Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 21, 2017
Health Report   PCR Protocol   Thawing Method
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RBRC No. RBRC04395  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129-Siglec1<tm1(HBEGF)Mtka>  
Former Common name CD169-DTR KO  
H-2 Haplotype No Data  
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. C57BL/6 background.  
Strain description CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.  
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Siglec1  
Symbol name sialic acid binding Ig-like lectin 1, sialoadhesin  
Chromosome 2  
Common name No Data  
Symbol description No Data  
 2 Symbol HBEGF  
Symbol name heparin-binding EGF-like growth factor (human)  
Chromosome 2  
Common name No Data  
Symbol description No Data  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 2  
Common name No Data  
Symbol description No Data  
References J Clin Invest. 2007 Aug 1;117(8):2268-2278.  
Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens.
Research applications Cre/loxP system,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Kenji Kohno, Ph.D. and Masato Tanaka, Ph.D. The recipient shall obtain a prior written approval from the depositor.  
Additional information
 1 Mouse of the Month Dec 2012
Genetic Background  
 2 Genotyping protocol <PCR>  
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology)  Tanaka, Masato 
Strain Status /
Availability
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