Strain Information | |
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Image | |
BRC No. | RBRC09773 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S4-Birc6<tm1Nai> |
Former Common name | Apollon knockout mice |
H-2 Haplotype | |
ES Cell line | J1 [129S4/SvJae] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Mikihiko Naito, The University of Tokyo, and Tetsuo Noda, The Cancer Institute of JFCR in 2002. E14 ES cell lines were used. C57BL/6 congenic strain. A floxed Neomycin resistance gene was removed by crossing to CAG-Cre line in B6 genetic background. |
Strain description | Birc6(baculoviral IAP repeat-containing 6)knockout mice. Homozygous mutants are embryonically or neonatally lethal. Heterozygous mice are born normally. |
Colony maintenance | |
References | Nat. Cell Biol., 6, 849-860 (2004). 15300255 J. Biol. Chem., 289, 3457-3467 (2014). 24302728 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)17 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP17loxP |
Ordering Information | |
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Donor DNA | SV40 Large T antigen nuclear localization signal(NLS), E. coli Beta galactosidase gene, phage P1 loxP site, mouse Birc6 genomic DNA |
Research application | Cre/loxP system Fluorescent Proteins/lacZ System |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Cell Biol., 6, 849-860 (2004). J. Biol. Chem., 289, 3457-3467 (2014).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Mikihiko Naito (National Institute of Health Sciences) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |