Strain Information | |
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Image | |
BRC No. | RBRC09798 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Ano5<tm1.2Naga> |
Former Common name | TMEM16E KO |
H-2 Haplotype | |
ES Cell line | Bruce 4 [B6.Cg-Thy1<a>] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Shigekazu Ngata, Jun Suzuki and Sayuri Gyobu at Osaka University in 2012. Bruce 4 ES cell line was used. Exon 2 and Neomycin resistance gene were removed by crossing CAG-Cre mice. |
Strain description | Ano5(anoctamin 5, Tmem16e) knockout mice. |
Colony maintenance | |
References | Mol. Cell Biol., 36, 645-659 (2015). 26667038 Neuromuscular Disorders, 25, 533-541 (2015). 25891276 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP7loxP |
Ordering Information | |
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Donor DNA | Phage P1 loxP site, mouse Ano6 genome DNA |
Research application | Cre/loxP system Mouse Models for Human Disease |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Cell Biol., 36, 645-659 (2015).The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Shigekazu Nagata (Osaka University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering:
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BRC mice in Publications |
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Li X, Wang L, Wang H, Qin A, Qin X. Ano5 modulates calcium signaling during bone homeostasis in gnathodiaphyseal dysplasia. NPJ Genom Med 7(1) 48(2022) 35982081 |