Strain Information | |
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Image | |
BRC No. | RBRC00073 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | BUS/Idr-bus |
Former Common name | BUS/Idr-bus |
H-2 Haplotype | |
ES Cell line | |
Background strain | KYF |
Appearance | brown agouti [A/A b/b C/C] |
Strain development | Developed by Satoshi Yonezawa, Institute for Developmental Research, Japan. Spontaneous mutation originally arosed in KYF/MsIdr-Jsr strain. |
Strain description | bustling spontaneous mutation arose in Cdh23 gene. Homozygous mutant mice exhibit behavioral abnormalities such as hyperactivity, circling, head tossing and head tilting with vestibulocochlear defects. Viable and fertile, but it is difficult for homozygous female to nurse pups. |
Colony maintenance | Heterozygote (female) x Homozygote (male) [or Crossing to BUS/Idr-+/+(RBRC00072)] |
References | Acta Otolaryngol., 117, 20-24 (1997). 9039475 Acta Otolaryngol. (Stockh), 116, 409-416 (1996). 8790740 Human Mutation, 27, 88-97 (2006). 16281288 Acta Otolaryngol. Suppl., 519, 286-293 (1995). 7610888 Hear. Res., 134, 116-122 (1999). 10452381 |
Health Report | |
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Examination Date / Room / Rack | 2024/02/26Room:4-BRack:K 2023/11/27Room:4-BRack:K 2023/08/28Room:4-BRack:K 2023/05/29Room:4-BRack:K 2023/02/27Room:4-BRack:K 2022/11/29Room:4-BRack:K 2022/08/29Room:4-BRack:K 2022/05/31Room:4-BRack:K |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Cdh23cadherin 23 (otocadherin)10Cdh23<v-bus>bustling4930542A03Rik, ahl, ahl1, bob, mdfw, nmf112, nmf181, nmf252, USH1D |
Ordering Information | |
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Donor DNA | |
Research application | Neurobiology Research Sensorineural Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Satoshi Yonezawa (Aichi Human Service Center) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (3 to 6 months) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |