Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00113  
Type Spontaneous Mutation Congenic   6wks,♂
Species Mus musculus  
Strain name C3H/HeSn-Ttf/+tf  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain C3H  
Appearance
 1 Appearance agouti, tufted (A/A, + tf/+tf)  
Genotype No Data  
 2 Appearance agouti, tail defects, tufted (A/A, T tf/+tf)  
Genotype No Data  
Strain development C3H/HeSn-Ttf/+tf strain was introduced to National Institute of Genetics from the Jackson laboratory in 1985.  
Strain description T, Brachyury, semidominant, Chr 17. Discovered in a laboratory stock. T/T homozygous embryos die at 10 days of gestation due to failure to form a normal mesoderm. T/+ heterozygote have a shortened tail and abnormal sacral vertebrae. T/t mice are tailless. tf/tf homozygous mice show repeated waves of hair loss and regrowth. tf gene is linked to the T/t complex.  
Colony maintenance Sister-brother mating
Heterozygote x Wild (tail defects x normal tail)  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol T  
Symbol name brachyury  
Chromosome 17  
Common name cou, Low, low ratio, Lr, me75, T1, Tl2, Tl3  
Symbol description No Data  
 2 Symbol Itpr3  
Symbol name inositol 1,4,5-triphosphate receptor 3; tufted  
Chromosome 17  
Common name No Data  
Symbol description No Data  
References No Data  
Research applications Dermatology Research,
Developmental Biology Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
Depositor Shiroishi, Toshihiko (National Institute of Genetics)  Shiroishi, Toshihiko 
Strain Status /
Availability
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