Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC00159  
Type Targeted Mutation and TransgeneCartagena   4wks
Species Mus musculus  
Strain name C57BL/6-p53 tm1Sia-Tg(gpt Delta)  
Former Common name C57BL/6-TgH(p53)-TgN(gpt delta)  
H-2 Haplotype No Data  
Donor strain Trp53: B6.CB-Trp53tm1Sia, gpt[Delta]: C57BL/6-Tg(gpt[Delta])  
Background strain C57BL/6  
Appearance
 1 Appearance black  
Genotype a/a  
Strain development The original p53 deficient mice had been introduced into C57BL/6 background for 13 generations by Dr. Niwa T at Hiroshima Univ (-1995). Then the mice were transfered to Dr. Kusakabe M. at RIKEN Life Science Center for further backcrossing to establish the B6 congenic strain. The gpt delta mice were crossed with C57BL/6-p53tm1 to establish a double mutant at RIKEN, and have been maintained by sister-brother mating for 8 generations.  
Strain description No Data  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Trp53  
Symbol name transformation-related protein 53  
Chromosome 11  
Common name p53  
Symbol description No Data  
 2 Symbol cat  
Symbol name E. coli Chloramphenicol acetyltransferase (CAT)  
Chromosome 17  
Common name No Data  
Symbol description No Data  
 3 Symbol gpt Delta  
Symbol name guanine phosphoribosyltransferase  
Chromosome 17  
Common name No Data  
Symbol description No Data  
 4 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 17  
Common name No Data  
Symbol description No Data  
 5 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 17  
Common name No Data  
Symbol description No Data  
 6 Symbol red/gam  
Symbol name lambda phage red/gam  
Chromosome 17  
Common name No Data  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 7 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References Environ. Mutagen Res., 22, 85-90 (2000).
Cancer Lett. 1999 Sep 1;143(2):241-4.
Cancer Res. 2001 May 15;61(10):3913-8.
Carcinogenesis. 2000 Nov;21(11):2049-56.
Environ Mol Mutagen. 1996;28(4):465-70.
Environ Mol Mutagen. 1999;34(1):1-8.
Environ Mol Mutagen. 1999;34(1):9-15.
Environ Mol Mutagen. 1999;34(2-3):72-9.
Oncogene. 1993 Dec;8(12):3313-22.
Phys Med 2001;17 Suppl 1:192-3.
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61.  











Research applications Apoptosis Research,
Cancer Research,
Cancer Research,
Cell Biology Research,
Immunology and Inflammation Research,
Immunology and Inflammation Research,
Mouse Models for Human Disease,
Mouse Models for Human Disease,
Toxicology Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
Depositor RIKEN, BioResource Center   
Strain Status /
Availability
(Expected delivery)

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