Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC00222  
Type Inbred  
Species Mus musculus  
Strain name SL/Kh  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain SL/KhStm  
Appearance
 1 Appearance albino  
Genotype A/A, B/B, c/c  
Strain development The spontaneous leukemia (SL) strain was originated from outbred Swiss albino mice, developed as a high-leukemia strain by Dr. K. Tsuchikawa in Mishima. At least 4 substrains, namely SL/Am, SL/Kh, SL/Ni, and SL/QDj had been established and maintained. SL/Kh and SL/Ni strains were deposited by Dr. Hayase Shisa, Saitama Cancer Center Institute. Pregnant females were transferred to RIKEN Tsukuba Institute, their babies were cleaned up by caesarean section, and introduced into the SPF facility.  
Strain description SL/Kh is a member of the spontaneous leukemia family of mice, originated from outbred Swiss albino mice. Based on genotype analysis using microsatellite markers, SL/Kh was defined as a recombinant congenic strain between proto-SL and AKR strain mice. This strain develops pre-B lympomas by reintegration of the endogenous ecotropic MuLV provirus into a number of common integration sites, including Stat5a, Evi3, c-Myc, Stat5b, N-Myc, and others. SL/Kh is useful for an excellent multifactorial disease model.  
Colony maintenance Sibling Mating
High incidence of pre-B lymphomas at early age  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Bomb1  
Symbol name bone marrow pre-B 1  
Chromosome 3  
Common name No Data  
Symbol description No Data  
 2 Symbol Tlsm1  
Symbol name thymic lymphoma susceptible 1  
Chromosome 7  
Common name No Data  
Symbol description No Data  
References Cancer Res. 1994 Jan 15;54(2):399-402.
Cancer Res. 1994 Jan 15;54(2):403-7.
Cancer Res. 1996 Aug 15;56(16):3716-20.
Cancer Res. 1999 Jun 1;59(11):2593-5.
J Exp Med. 1994 Dec 1;180(6):2155-62.
J Natl Cancer Inst. 1987 Oct;79(4):781-7.
Lab Anim Sci. 1996 Aug;46(4):410-7.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8253-8. Epub 2002 Jun 4.  












Research applications Cancer Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
Depositor Shisa, Hayase (Saitama Cancer Center)  Shisa, Hayase 
Strain Status /
Availability
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