Strain Information | |
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Image | |
BRC No. | RBRC00300 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S6-Rela<tm1Yuo>/1Rbrc |
Former Common name | RelA KO, RKO-1 |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6JJcl |
Appearance | black |
Strain development | |
Strain description | |
Colony maintenance | |
References | Proc. Natl. Acad. Sci. USA, 96, 2994-2999 (1999). 10077625 J. Exp. Med., 185, 953-961 (1997). 9120401 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)19Rela<tm1Yuo>targeted mutation 1, Yuichi Obatap65 NFkB, p65 NF-kappa B, avian reticuloendotheliosis viral (v-rel) oncogene homolog A Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)19neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, mouse RelA genomic DNA |
Research application | Cell Biology Research Immunology and Inflammation Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Exp Med., 185, 953-961 (1997). Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice. |
Depositor | Takahiro Doi (RIKEN) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS. A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J Immunol 179(10) 6596-603(2007) 17982049 Kawauchi K, Araki K, Tobiume K, Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 10(5) 611-8(2008) 18391940 |