Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00301  
Type Targeted MutationCartagena   8wks,♂
Species Mus musculus  
Strain name B6.129S6-Rela<tm1Yuo>/2Rbrc  
Former Common name RelA KO, RKO-2  
H-2 Haplotype No Data  
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]  
Donor strain 129S6/SvEvTac via EK.CCE ES cell line  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype No Data  
Strain description No Data  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Rela  
Symbol name v-rel reticuloendotheliosis viral oncogene homolog A  
Chromosome 19  
Common name p65 NFkB, p65 NF-kappa B, avian reticuloendotheliosis viral (v-rel) oncogene homolog A  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 19  
Common name neo; neomycin;  
Symbol description No Data  
References J Exp Med. 1997 Mar 3;185(5):953-61.
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9.  
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses.
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses.
Research applications Cell Biology Research,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J Exp Med., 185, 953-961 (1997).
Any patent rights and other intellectual properties are retained by the depositor. Users should contact the depositor in the case of application for any patents with the results from these mice.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Doi, Takahiro (RIKEN, BioResource Center)  Doi, Takahiro 
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