Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jun 20, 2019
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RBRC No. RBRC00388  
Type Spontaneous Mutation   wks
Species Mus musculus  
Strain name PROD-Cacna1a<tg-rol>/NemOdaRbrc  
Former Common name PROD-rol/+  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance agouti with white spot  
Genotype A/A B/? C/C s/s  
Strain development Developed by Dr. Sen-ichi Oda, Nagoya University. Cacna1a<tg-rol> arose spontaneously in descendants of (SIII x C57BL/6)F1 in 1969.  
Strain description Rolling mouse Nagoya, PROD-Cacna1a<tg-rol>/NemOdaRbrc. Cacna1a gene is a voltage-gated pore-forming membrane protein, mediates Ca2+ influx across presynaptic and somatodendritic membranes, thereby triggering fast neurotransmitter release and other key neuronal responses. Homozygous mutant mice exhibit a severe ataxia, episodic dyskinesia, and cerebellar atrophy.  
Colony maintenance Homozygous mutant mice are identifiable between 10 and 14 days old by a creeping or rolling gait.
homozygous females are fertile but do not breed well.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Cacna1a  
Symbol name calcium channel, voltage-dependent, P/Q type, alpha 1A subunit  
Chromosome 8  
Common name alpha1A, Cacnl1a4, Ccha1a, EA2, MHP1, nmf352, SCA6  
Symbol description No Data  
References Biomed. Res., 1, 88-90 (1980).
Genetic Approches to Developmental Neurobiology (TSUKADA Yasuzo, ed), University of Tokyo Press, Tokyo, pp. 171-181 (1982).
Jpn. J. Genet., 56, 295-299 (1981).
Dev Psychobiol. 1986 Jan;19(1):67-77.
J Neurosci. 2000 Aug 1;20(15):5654-62.
Neurosci Lett. 1999 Apr 30;266(1):49-52.
Neurosci Res. 1988 Apr;5(4):316-24.  



Research applications Developmental Biology Research,
Genetics Research,
Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 No Data  
Depositor Oda, Senichi (Nagoya University)  Oda, Senichi 
Strain Status /
Availability
(Expected delivery)

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