Strain Information | |
---|---|
Image | |
BRC No. | RBRC00422 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | C.Cg-Cpox<nct>/JmsRbrc |
Former Common name | NCT, BALB/c-nct/nct |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | albino [A/A b/b c/c] |
Strain development | Cataract mutation arose spontaneously in the multiple breeding colony. The mutant mice were backcrossed to BALB/c (1988). |
Strain description | Nakano cataract mice, spontaneous recessive mutant. Homozygous mutant mice develop cataracts. A spontaneous G to T transversion was occurred in the Cpox gene, resulting in the amino acid substitution of Leu for Arg at position 380. |
Colony maintenance | Sibling Mating (Homozyogote x Homozygote) |
References | Genomics, 50, 119-120 (1998). 9628833 Exp. Eye Res., 112, 45-50 (2013). 23631845 Exp. Eye Res., 75, 745-751 (2002). 12470976 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
---|---|
Donor DNA | |
Research application | Sensorineural Research |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Hiroshi Hiai (Kyoto University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
---|
Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M. A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice. Exp Anim 64(2) 171-9(2015) 25736709 Liu C, Miyahara H, Dai J, Cui X, Li Y, Kang X, Higuchi K, Mori M. Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice. Exp Eye Res 215 108905(2022) 34968474 Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K. Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res 112 45-50(2013) 23631845 Narita M, Wang Y, Kita A, Omi N, Yamada Y, Hiai H. Genetic analysis of Nakano Cataract and its modifier genes in mice. Exp Eye Res 75(6) 745-51(2002) 12470976 Xiaojing Kang, Shin Shimada, Hiroki Miyahara, Keiichi Higuchi, Masayuki Mori BALB.NCT-Cpox is a unique mouse model of hereditary coproporphyria Molecular Genetics and Metabolism Reports 35 100964(2023) 36967721 |