Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00457  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129P2-Prkcd<tm1Kin>  
Former Common name PKCδ Knockout mice  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Keiichi Nakayama, Kyusyu University.  
Strain description Protein kinase C (PKC) delta is a member of PKC family which phosphorylates a wide variety of protein targets and is known to be involved in diverse cellular signaling pathways. In PKC family members, PKC delta has a unique function to supress cell proliferation. PKC-delta deficient mice exhibit expansion of the B- lymphocyte population and show autoimmune disease after 6 months of age.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Prkcd  
Symbol name protein kinase C, delta  
Chromosome 14  
Common name D14Ertd420e, PKC[d], Pkcd, PKCdelta  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 14  
Common name neo; neomycin;  
Symbol description No Data  
References   
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University)  Nakayama, Keiichi 
Strain Status /
Availability
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