Strain Information | |
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Image | |
BRC No. | RBRC00522 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6;129-Rag2<tm1Fwa> Il2rb<tm1Mak>/Rbrc |
Former Common name | C57BL/6-Rag2<tm1Fwa>-IL2rb<tm1Och> |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | black |
Strain development | 1998 by Koyasu at Keio Univ. School of Med.Original :Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USAIL2rbtm1Och:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, Canada |
Strain description | They lack T, B and NK cells. Furthermore, Macrophages and DCs have some functional defects. |
Colony maintenance | Nothing special. Breed well. |
References | Nat. Immunol., 2, 1138-1143 (2001). 11702064 Eur. J. Immunol., 31, 3147-3152 (2001). 11745331 Science, 268, 1472-1476 (1995). 7770771 J. Immunol., 157, 4379-4389 (1996). 8906813 Cell, 68, 855-867 (1992). 1547487 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Il2rbinterleukin 2 receptor, beta chain15Il2rb<tm1Mak>targeted mutation 1, Tak W MakCD122, IL-2 receptor beta chain, Il-2Rbeta, p70 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)15neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E.coli neo, herpes simplex virus thymidine kinase polyA additional signal, mouse Rag2 genomic DNA, mouse IL2rb genomic DNA |
Research application | Cell Biology Research Immunology and Inflammation Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca). |
Depositor | Shigeo Koyasu (Keio University) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |