Strain Data Sheet
Data update: Aug 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC00695  
Type TransgeneCartagena   8wks,♀
Species Mus musculus  
Strain name B6.Cg-Tg(KRT14-HGF)43Takk/Rbrc  
Former Common name hk14-HGF (human cytokeratin14 promoter + human hepatocyte growth factor)  
H-2 Haplotype No Data  
Background strain No Data  
 1 Appearance black  
Genotype a/a B/B C/C +/+  
 2 Appearance black with an aberrant pigmentation in the skin  
Genotype a/a B/B C/C Tg/?  
Strain development Developed by Dr. Takahiro Kunisada at Tottori University in 2000. The human HGF cDNA fragment under the contorl of human keratin 14 promoter was injected into the pronuclei of B6D2F1 fertilized eggs.  
Strain description These transgenic mice develop prominent epidermal pigmentation by overexpression of the human HGF gene controlled by the human keratin 14 promoter. The phenotypes of these transgenic mice conform with that of human dermal melanocytosis. This strain is a useful animal model for dermal melanocytosis.  
Colony maintenance Sibling Mating (Hemizygote x wild-type, Hemizygote)  
Health Report No Data  
Gene Details
Promoter human cytokeratin14 promoter  
 1 Symbol HGF  
Symbol name hepatocyte growth factor (human)  
Chromosome UN  
Common name C230052L06Rik, HGF/SF, NK1, NK2, scatter factor, SF/HGF  
Symbol description No Data  
References Mech Dev. 2000 Jun;94(1-2):67-78.  
Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Kunisada, Takahiro (Gifu University, Graduate School of Medicine)  Kunisada, Takahiro 
Strain Status /
(Expected delivery)

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