Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00752  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129P2-Tnfrsf5<tm1Kik>/Rbrc  
Former Common name CD40 Knockout mice  
H-2 Haplotype No Data  
Donor strain 129P2/OlaHsd via E14.1 ES cell line  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hitoshi Kikutani, Institute for Molecular and Cellular Biology, Osaka University in 1994.  
Strain description CD40 knockout mice. Exon 3 of the CD40 was replaced with a neo cassette. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation. Homozygous mutant mice for CD40 targeted mutation exhibit impaired immunoglobulin class switching, and the germinal center formation was defective. Homozygous mice are viable and fertile.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Tnfrsf5  
Symbol name tumor necrosis factor receptor superfamily, member 5  
Chromosome 2  
Common name Bp50, Cd40, IGM, p50  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 2  
Common name neo; neomycin;  
Symbol description No Data  
References Immunity. 1994 Jun;1(3):167-78.  
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunity, 1, 167-178 (1994).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Kikutani, Hitoshi (Osaka university)  Kikutani, Hitoshi 
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