Strain Data Sheet
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Data update: May 20, 2019
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RBRC No. RBRC00754  
Type Targeted Mutation and TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Cd40<tm1Kik> Tg(Igh-CD40)1Kik/Rbrc  
Former Common name CD40 transgenic mice  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Hitoshi Kikutani, Research Institute for Microbial Diseases, Osaka University in 2002.  
Strain description Transgenic mice expressing wild-type human CD40 gene in a mouse CD40 deficient background. CD40/Tnfrsf5 (tumor necrosis factor receptor superfamily, member 5) is essential for T cell-dependent immunoglobulin class switching and germinal center formation.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Tnfrsf5  
Symbol name tumor necrosis factor receptor superfamily, member 5  
Chromosome 2  
Common name Bp50, Cd40, IGM, p50  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 2  
Common name neo; neomycin;  
Symbol description No Data  
Promoter mouse E m, IgH promoter, rabbit beta-globin poly A  
 3 Symbol TNFRSF5  
Symbol name tumor necrosis factor receptor superfamily, member 5 (human)  
Chromosome UN  
Common name Bp50, Cd40, IGM, p50  
Symbol description No Data  
References Int Immunol. 2002 Mar;14(3):319-29.
Nature. 1985 Jul 4-10;316(6023):67-9.  
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Inter. Immunol., 14, 319-329 (2002).  
Additional information
 1 No Data  
Depositor Kikutani, Hitoshi (Osaka university)  Kikutani, Hitoshi 
Strain Status /
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