Strain Data Sheet
Data update: Jun 20, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC00763  
Type Spontaneous Mutation  
Species Mus musculus  
Strain name WS4  
Former Common name Mouse model for Waardenburg syndrome type 4-Hirschsprung disease type 2  
H-2 Haplotype No Data  
Donor strain BALB/c x MSM Mixed  
Background strain MSM [Mus musculus molossinus]  
 1 Appearance white-bellied agouti  
Genotype A/A B/B C/C WS4/+  
 2 Appearance a few white spots, black eyes  
Genotype A/A B/B C/C WS4/WS4  
Strain development Developed by Yoshibumi Matsushima, Saitama Cancer Center. Spontaneous mutation arose in BALB/c and MSM background. The mutant mice were backcrossed to MSM/Ms.  
Strain description A animal model for Waardenburg syndrome type 4. Waardenburg syndrome (WS) is a hereditary auditory-pigmentary syndrome with hearing impairment and pigment anomaly, and the WS type 4 is associated with Hirschsprung disease. WS4 mutant mice were spontaneously arose in a breeding colony with BALB/c and MSM mixed background. Homozygous mutant mice show piebald and deafness, and most of them die between 2 and 4 weeks after birth due to megacolon. The results of allelism tests indicated that WS4 is allelic with Ednrb mutant mice (piebald-lethal and JF1).  
Colony maintenance Heterozygote x Wild-type [MSM/Ms]  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ednrb  
Symbol name endothelin receptor type B  
Chromosome 14  
Common name ET-B, ETb, Sox10m1  
Symbol description No Data  
References Mamm Genome. 2002 Jan;13(1):30-5.  
A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene.
Research applications Mouse Models for Human Disease  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Matsushima, Yoshibumi (Saitama Cancer Center)  Matsushima, Yoshibumi 
Strain Status /
(Expected delivery)

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