Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00765  
Type Spontaneous Mutation  
Species Mus musculus  
Strain name INAD  
Former Common name infantile neuroaxonal dystrophy: INAD  
H-2 Haplotype No Data  
Background strain C57BL/6  
Appearance
 1 Appearance black  
Genotype (a/a B/B C/C)  
Strain development Discovered in a C57BL/6 breeding colony. Developed by Dr. Yoshibumi Matsushima, Saitama Cancer Center in 2005.  
Strain description The spontaneous mutation that was discovered in a C57BL/6 breeding colony. Homozygous mutant mice exhibit the incoordinated limbs and lean body in the lower half of the body, and die from 4 to 5 weeks after birth. In these mice, a neurodystrophic change appearing as spheroid bodies in central and peripheral nervous system is observed. This strain is useful as a mouse model for infantile neuroaxonal dystrophy (INAD).  
Colony maintenance Sibling Mating (Heterozygote x Heterozygote) or Transplant-Cross-Intercross (maintenace by ovary transplantation, Homozygote x Heterozygote)
Homozygous mutant mice die before sexual maturity.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol inad  
Symbol name infantile neuroaxonal dystrophy  
Chromosome 1  
Common name infantile neuroaxonal dystrophy  
Symbol description No Data  
References Mamm Genome. 2005 Feb;16(2):73-8.  
A new mouse model for infantile neuroaxonal dystrophy, inad mouse, maps to mouse chromosome 1.
Research applications Mouse Models for Human Disease  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 Mouse of the Month Mar 2005  
Depositor Matsushima, Yoshibumi (Saitama Cancer Center)  Matsushima, Yoshibumi 
Strain Status /
Availability
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