Strain Information | |
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Image | |
BRC No. | RBRC00765 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | INAD |
Former Common name | infantile neuroaxonal dystrophy: INAD |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6 |
Appearance | black [(a/a B/B C/C)] |
Strain development | Discovered in a C57BL/6 breeding colony. Developed by Dr. Yoshibumi Matsushima, Saitama Cancer Center in 2005. |
Strain description | The spontaneous mutation that was discovered in a C57BL/6 breeding colony. Homozygous mutant mice exhibit the incoordinated limbs and lean body in the lower half of the body, and die from 4 to 5 weeks after birth. In these mice, a neurodystrophic change appearing as spheroid bodies in central and peripheral nervous system is observed. This strain is useful as a mouse model for infantile neuroaxonal dystrophy (INAD). |
Colony maintenance | Sibling Mating (Heterozygote x Heterozygote) or Transplant-Cross-Intercross (maintenace by ovary transplantation, Homozygote x Heterozygote)Homozygous mutant mice die before sexual maturity. |
References | Mamm. Genome, 16, 73-78 (2005). 15859351 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter |
Ordering Information | |
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Donor DNA | |
Research application | Mouse Models for Human Disease |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Yoshibumi Matsushima (Saitama Cancer Center) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Mouse of the Month Mar 2005 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |