Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC00804  
Type Targeted Mutation CongenicCartagena   8wks,♂
Species Mus musculus  
Strain name B6.129P2-S100b<tm1Ito>/ItoRbrc  
Former Common name S100b-KO  
H-2 Haplotype No Data  
ES cell line E14 [129P2/OlaHsd]  
Donor strain 129P2/OlaHsd via E14 ES cell line  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed Hiroshi Nishiyama and Shigeyoshi Itohara, Brain Science Institute, RIKEN. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6.  
Strain description S100b gene knockout mice. Exon 2 and part of exon 3 of S100b gene were replaced with a floxed neo cassette. Homozygous mutant mice are viable and fertile.  
Colony maintenance Sibling Mating  
Health Report
Gene Details
Promoter No Data  
 1 Symbol S100b  
Symbol name calcium-binding protein S100b  
Chromosome 10  
Common name Bpb  
Symbol description No Data  
 2 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 10  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 10  
Common name neo; neomycin;  
Symbol description No Data  
References Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42. Epub 2002 Mar 12.  
Glial protein S100B modulates long-term neuronal synaptic plasticity.
Research applications Neurobiology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Natl. Acad. Sci. USA, 99, 4037-4042 (2002).  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Itohara, ShigeYoshi (RIKEN Center for Brain Science)  Itohara, ShigeYoshi 
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