Strain Data Sheet
Data update: Apr 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC00994  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129S4-Sh2b1<tm1Ayos>/Rbrc  
Former Common name SH2-B knockout mice, C57BL/6.129 SH2-B -/-  
H-2 Haplotype No Data  
ES cell line AK7 [129S4/SvJaeSor]  
Donor strain 129S4/SvJaeSor via AK7 ES cell line  
Background strain C57BL/6 and 129 mixed  
 1 Appearance No Data  
Genotype No Data  
Strain development C57BL/6 X 129 mix background  
Strain description No Data  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Sh2bpsm1  
Symbol name SH2-B PH domain containing signaling mediator 1  
Chromosome 7  
Common name Irip, SH2-B, SH2-Bb  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 7  
Common name neo; neomycin;  
Symbol description No Data  
References Mol Cell Biol. 2002 May;22(9):3066-77.
Nat Genet. 2001 Mar;27(3):293-8.  
SH2-B is required for both male and female reproduction.
SH2-B is required for both male and female reproduction.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Mol. Cell. Biol., 22, 3066-3077 (2002).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The depositor should be a co-author in the articles when the users publish their data using these mice for 1 year after provided.
Users should contact the depositor in the case of application for any patents with the results from these mice.  
Additional information
 1 Lab HP (Japanese)  
 2 Genotyping protocol <PCR>  
Depositor Takagi, Satoshi (National Center for Global Health and Medicine)  Takagi, Satoshi 
Strain Status /
(Expected delivery)

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