Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC01002  
Type TransgeneCartagena  
Species Mus musculus  
Strain name C.Cg-Tg(ITGAM-Aif1)Y/Rbrc  
Former Common name AIF-1 Tgm Line Y BALB/c background  
H-2 Haplotype No Data  
Donor strain B6;D2-Tg(CD11B-Aif1)Y  
Background strain BALB/cAJcl  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Drs. Watano and Iwabuchi in 2000. AIF-1 transgenic mice were backcrossed to BALB/c.  
Strain description Aif1, allograft inflammatory factor-1, was originally identified as one of the expressed genes in infiltrating macrophages. This transgenic strain expresses Aif1 strongly in monocytes and macrophages (CD11b-positive cells), and is useful for analysis of the inflammation and immune response when Aif1 gene is overexpressed.  
Colony maintenance Backcross to BALB/cA (Hemizygote x BALB/cA Jcl)  
Health Report No Data  
Gene Details
Promoter human CD11b promoter, hGH  
 1 Symbol Aif1  
Symbol name allograft inflammatory factor-1  
Chromosome UN  
Common name D17H6S50E, G1, Iba1 , AIF-1  
Symbol description No Data  
References Am J Reprod Immunol. 2003 Jul;50(1):104-12.
Blood. 1995 Jan 15;85(2):319-29.
Immunology 2001 Nov;104(3):307-16.
Immunology. 2003 Sep;110(1):112-9.  
Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption.
Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption.
Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption.
Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Immunology, 110, 112-119 (2003).  
Additional information
 1 No Data  
Depositor Iwabuchi, Kazuya (Hokkaido University)  Iwabuchi, Kazuya 
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