Strain Information | |
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Image | |
BRC No. | RBRC01080 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129S-Drd1a<tm1Mok> |
Former Common name | D1R KO, B6-D1R KO |
H-2 Haplotype | |
ES Cell line | CCE/EK.CCE [129S/SvEv-Gpi1<c>] |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences. |
Strain description | D1R (Ded1a) gene knockout mice. |
Colony maintenance | Heterozygote x Wild-type [C57BL/6JJcl] |
References | J. Neurosci., 28(50):13390-13400 (2008). 19074012 Front Integr Neurosci., 8, 56 (2014). 25076876 Front Cell Dev Biol., 3, 38 (2015). 26137459 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Drd1dopamine receptor D1A13Drd1<tm1Mok>targeted mutation 1, Motoya KatsukiC030036C15Rik, D1 receptor, Drd-1, Drd1, Gpcr15 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter EcogptE.coli xanthine phosphoribosyltransferase13Ecogptmouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)13neo; neomycin;herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli xanthine phosphoribosyltransferase(Ecogpt), herpes simplex virus thymidine kinase promoter (HSV tk promoter), E coli neo, mouse dopamine receptor1 genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neuroscience, 28(50), 13390-13400 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Toshikuni Sasaoka (Niigata University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Mouse of the Month Oct 2009 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Nguyen CL, Tran AH, Matsumoto J, Hori E, Uwano T, Ono T, Nishijo H. Hippocampal place cell responses to distal and proximal cue manipulations in dopamine D2 receptor-knockout mice. Brain Res 1567 13-27(2014) 24747614 Nagatomo K, Suga S, Saitoh M, Kogawa M, Kobayashi K, Yamamoto Y, Yamada K. Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse. Front Neuroanat 11 3(2017) 28203148 Hu Z, Oh EH, Chung YB, Hong JT, Oh KW. Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration. Korean J Physiol Pharmacol 19(2) 89-97(2015) 25729269 |