Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01130  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129P2-Ugt8a<tm1Pop>/Rbrc  
Former Common name Ceramide galactosyltransferase (CGT)-deficient mice  
H-2 Haplotype No Data  
ES cell line BK4 [129P2/OlaHsd]  
Donor strain 129P2/OlaHsd via BK4 ES cell line  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Brain Popko, University of North Carolina in 1996.  
Strain description CGT-deficient mice fail to make galactolipid galactocerebroside and its sulfated derivative that are normal myelin constitutents. Mutant mice exhibit tremors, ataxia, progressive hindlib paralysis and vaculoe formation in ventral spinal cord due to abnormal myelin sheath.
B6.129P2-Ugt8a<tm1Pop>. Ceramide galactosyltransferase, CGT is a key enzyme in the biosynthesis of galactocerebroside, GalC. Homozygous mutant mice for CGT gene show tremor, ataxia progressive hind limb paralysis and extensiv vacuolation of the ventral spinal cord.  
Colony maintenance Sibling Mating  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Ugt8  
Symbol name UDP-glucuronosyltransferase 8  
Chromosome 3  
Common name Cgt  
Symbol description No Data  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 3  
Common name neo; neomycin;  
Symbol description No Data  
References Cell. 1996 Jul 26;86(2):209-19.
J Biol Chem. 2000 Jul 28;275(30):22623-6.
J Lipid Res. 2000 Aug;41(8):1237-43.
Tanpakushitsu Kakusan Koso 1998 Dec;43(16 Suppl):2318-24.
Tanpakushitsu Kakusan Koso. 2001 Jan;46(1):45-53.  
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability.
Research applications Cell Biology Research,
Neurobiology Research  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Popko, Brian (The University of Chicago)  Popko, Brian 
Strain Status /
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