Strain Information | |
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Image | |
BRC No. | RBRC01144 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;129S7-Heyl<tm1Kkb>/YsaRbrc |
Former Common name | hairy and enhancer of split-related 3 Knock in (LacZ) |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6NJcl |
Appearance | black [a/a , B/B , C/C] |
Strain development | B6;129S7-Heyl<tm1Kkb>. The Heyl gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play important roles in mediating the Notch signaling pathway. It is suggested that the Heyl gene has a role of the differentiation of retina. This strain is useful for elucidation of the Notch-signaling pathway mechanism. |
Strain description | Developed by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999. Combined loxP site and lacZ-Neo cassette was transferred into Heyl gene. |
Colony maintenance | Sibling mating.Homozygous mutant mice are fertile and display no obvious defects. |
References |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter lacZbeta-galactosidase (E. coli)4 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP4loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP4loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)4neo; neomycin; |
Ordering Information | |
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Donor DNA | mouse hairy and enhancer of split-related 3 genomic DNA, E. coli lacZ, E. coli neo, phage P1 loxP |
Research application | |
Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Yumiko Saga (National Institute of Genetics) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |