Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
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RBRC No. RBRC01151  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name hairy and enhancer of split-related 1  
Former Common name hesr1, hairy and enhancer of split-related 1  
H-2 Haplotype No Data  
ES cell line AB1 [129S7/SvEvBrd-Hprt<+>]  
Donor strain 129S7/SvEvBrd via AB1 ES cell line  
Background strain C57BL/6NJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999. A loxP-flanked neo cassette was transferred into AB1 ES cells to replace the bHLH region, from exon 1 to exon 4. C57BL/6 and 129 mixed background.  
Strain description B6;129S7-Hey1<tm1Kkb>. Hey1 gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play a important roles in mediating Notch signaling in the developing cardiac and vascular systems.  
Colony maintenance Sibling Mating
Homozygous mutant mice are viable and fertile.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Hey1  
Symbol name hairy and enhancer of split-related 1  
Chromosome 3  
Common name Hairy/E(spl)-related with YRPW motif 1, Herp2, hesr-1, HRT1  
Symbol description No Data  
 2 Symbol IRES  
Symbol name internal ribosomal entry site (EMCV)  
Chromosome 3  
Common name internal ribosomal entry site from EMCV  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 3  
Common name No Data  
Symbol description E. coli beta galactosidase  
 4 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 3  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 5 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 3  
Common name neo; neomycin;  
Symbol description No Data  
References   
Research applications Cell Biology Research,
Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Saga Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Saga, Yumiko (National Institute of Genetics)  Saga, Yumiko 
Strain Status /
Availability
(Expected delivery)

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