Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01154  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(Six3-cre)69Frty  
Former Common name TgN(Six3 Cre)69Frt; Six3Cre#69  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Yasuhide Furuta, University of Texas, M.D. Anderson Cancer Center. The Six3-cre transgene fragment was injected into the pronuclei of B6D2F2 fertilized eggs. The mice were crossed to C57BL/6 (N5 times).  
Strain description Transgenic mice expressing Cre recombinase in a central region of the developing retina and widely in the ventral forebrain. Useful for tissue-specific gene activation/inactivation approaches. In particular, consequences of gene activation/inactivation in Cre-expressing cells within the retina can be assessed in direct comparisons to the surrounding non-Cre-expressing cells in an animal. Line 69 (RBRC01154), Line 22 (RBRC01153).  
Colony maintenance Carrier x Carrier  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 2 Symbol nls  
Symbol name SV40 large T antigen nuclear localization signal (NLS)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse Six3 promoter  
 3 Symbol cre  
Symbol name Phage P1 Cre recombinase  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Genesis. 2000 Feb;26(2):130-2.  
Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice.
Research applications Cell Biology Research,
Cre/loxP system,
Genetics Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genesis, 26, 130-132 (2000).  
Additional information
 1 Mouse of the Month June 2006  
 2 Genotyping protocol <PCR>  
Depositor Furuta, Yasuhide (University of Texas, M.D. Anderson Cancer Center)  Furuta, Yasuhide 
Strain Status /
Availability
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