Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC01188  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc  
Former Common name t(7;11)AML NUP98-HOXA9 transgenic (Tg) mice  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Kakuro Nakamura, NIH in 1996. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J over 10 times.  
Strain description B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak. This transgenic mice express the chimeric NUP98-HOXA9 gene in the myeloid lineage. About 20% of mice with this transgene exhibit myeloproliferative disorder and acute myeloid leukemia (AML).  
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol CTSG  
Symbol name Cathepsin G (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 2 Symbol HOXA9  
Symbol name homeo box A9 (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter human Cathepsin G promoter  
 3 Symbol NUP98  
Symbol name nucleoporin 98 (human)  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Blood 2005 Jan 15;105(2):784-93. Epub 2004 Sep 28.  
Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.
Research applications Cancer Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.  
Additional information
 1 The Cancer Institute of JFCR  
 2 Mouse of the Month Mar 2006  
 3 Genotyping protocol <PCR>  
Depositor Nakamura, Takuro (Japanese Foundation for Cancer Research)  Nakamura, Takuro 
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