Strain Information | |
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Image | |
BRC No. | RBRC01188 |
Type | Transgene |
Species | Mus musculus |
Strain name | B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak/TanakRbrc |
Former Common name | t(7;11)AML NUP98-HOXA9 transgenic (Tg) mice |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Kakuro Nakamura, NIH in 1996. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J over 10 times. |
Strain description | B6.Cg-Tg(CTSG-NUP98/HOXA9)1589Tanak. This transgenic mice express the chimeric NUP98-HOXA9 gene in the myeloid lineage. About 20% of mice with this transgene exhibit myeloproliferative disorder and acute myeloid leukemia (AML). |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Blood, 105, 784-793 (2005). 15454493 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter CTSGCathepsin G (human)UNCTSG Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HOXA9homeo box A9 (human)UNHOXA9 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter NUP98nucleoporin 98 (human)UNNUP98human Cathepsin G promoter |
Ordering Information | |
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Donor DNA | human Cathepsin G genomic DNA, human NUP98-HOXA9 cDNA |
Research application | Cancer Research |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. |
Depositor | Takuro Nakamura (Japanese Foundation for Cancer Research) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Mouse of the Month Mar 2006 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Funasaka T, Nakano H, Wu Y, Hashizume C, Gu L, Nakamura T, Wang W, Zhou P, Moore MA, Sato H, Wong RW. RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis. Cell Cycle 10(9) 1456-67(2011) 21467841 |