Strain Data Sheet

RBRC01190

Strain Information

Image
BRC No.RBRC01190
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129-Bcl11a<tm1Ngc>/Rbrc
Former Common nameEvi9/BclIIa Knockout mice
H-2 Haplotype
ES Cell lineCJ7 [129/SvlmJ]
Background strain
Appearancewhite-bellied agouti [A<w>/A<w> B/B C/C]
Strain developmentDeveloped by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.
Strain descriptionDeveloped by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.
Colony maintenanceSibling Mating (Heterozygote x Wild-type, Heterozygote)Homozygous mutant mice die within 3-4hrs after birth.
ReferencesNat. Immunol., 4, 525-532 (2003). 12717432

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Bcl11aB-cell CLL/lymphoma 11A (zinc finger protein)11Bcl11a<tm1Ngc>targeted mutation 1, Neal G Copeland2810047E18Rik, 4930538E20Rik, COUP-TF interacting protein 1, CTIP1, Evi9, mKIAA1809, mouse myeloid leukemia gene

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
GHGrowth hormone polyA (Bovine)11GH

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
SAadenovirus major late transcript splice acceptor (SA) sequence11SA

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
lacZbeta-galactosidase (E. coli)11

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)11neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter)

Ordering Information

Donor DNAadenovirus major late transcript splice acceptor (SA) sequence, E. coli lacZ, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, bovine growth hormone poly A, mouse Bcl11a genomic DNA
Research applicationFluorescent Proteins/lacZ System
Immunology and Inflammation Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Immunol., 6, 525-532 (2003).
DepositorTakuro Nakamura (Japanese Foundation for Cancer Research)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data