Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01190  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name 129-Bcl11a<tm1Ngc>/Rbrc  
Former Common name Evi9/BclIIa Knockout mice  
H-2 Haplotype No Data  
ES cell line CJ7 [129/SvlmJ]  
Donor strain 129S1/SvImJ via CJ7 ES cell line  
Background strain No Data  
Appearance
 1 Appearance white-bellied agouti  
Genotype A/A B/B C/C  
Strain development Developed by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.  
Strain description Developed by Drs. Pentao Liu and Neal G Copeland at NIH in 1999. A PGK-neo cassette replaced was transfered into CJ7 ES cells to replace exon 1 of Bcl11a gene.  
Colony maintenance Sibling Mating (Heterozygote x Wild-type, Heterozygote)
Homozygous mutant mice die within 3-4hrs after birth.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Bcl11a  
Symbol name B-cell CLL/lymphoma 11A (zinc finger protein)  
Chromosome 11  
Common name 2810047E18Rik, 4930538E20Rik, COUP-TF interacting protein 1, CTIP1, Evi9, mKIAA1809, mouse myeloid leukemia gene  
Symbol description No Data  
 2 Symbol GH  
Symbol name Growth hormone polyA (Bovine)  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References Nat Immunol. 2003 Jun;4(6):525-32. Epub 2003 Apr 28.  
Bcl11a is essential for normal lymphoid development.
Research applications Fluorescent Proteins/lacZ System,
Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Immunol., 6, 525-532 (2003).  
Additional information
 1 The Cancer Institute of JFCR  
 2 Genotyping protocol <PCR>  
Depositor Nakamura, Takuro (Japanese Foundation for Cancer Research)  Nakamura, Takuro 
Strain Status /
Availability
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