Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01200  
Type Transgene CongenicCartagena   wks
Species Mus musculus  
Strain name NZW.C3-Tg(Mt1-Il5)6Ato  
Former Common name NZW.IL-5  
H-2 Haplotype No Data  
Donor strain C3H/HeN-Tg(Mt1-Il5)6Ato  
Background strain NZW  
Appearance
 1 Appearance albino  
Genotype b/b c/c p/p  
Strain development Generated by Kiyoshi Takatsu, Kumamoto University Medical School. The transgene was injected into the pronuclei of C3H fertilized eggs. C57BL/6 (RBRC01908) and BALB/c (RBRC05910) background (Developed by Institute of Medical Science, University of Tokyo), NZW background (RBRC01200) (Developed by Juntendo University School of Medicine).  
Strain description Mt1-Il5 transgenic mice. These transgenic mice express mouse IL-5 under the control of the Mt1 promoter.  
Colony maintenance Carrier x Noncarrier [or Crossing to NZW/NSlc] Tg mice show no obvious abnormality.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol HBB2  
Symbol name rabbit beta-globin splice acceptor  
Chromosome UN  
Common name No Data  
Symbol description No Data  
 2 Symbol HBB2  
Symbol name rabbit beta-globin splice donor  
Chromosome UN  
Common name No Data  
Symbol description No Data  
Promoter mouse metallothionein promoter, rabbit beta-globin  
 3 Symbol Il5  
Symbol name interleukin 5  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References Eur J Immunol. 2004 Oct;34(10):2740-9.
J Exp Med. 1991 Feb 1;173(2):429-37.  
Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.
Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Eur. J. Immunol., 34, 2740-2749 (2004).  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Hirose, Sachiko (Juntendo University)  Hirose, Sachiko 
Strain Status /
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