Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC01306  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.Cg-Hbegf<tm1.1Mek>/MekRbrc  
Former Common name HB-EGF Knockout mice(BL6)(HBdel#80/B6)  
H-2 Haplotype No Data  
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]  
Donor strain C57BL/6J  
Background strain C57BL/6J  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs Ryo Iwamoto, Eisuke Mekada et al., at Osaka University in 2003.
The HB-EGF null mice were generated by crossing with CAG-Cre transgenic mice.  
Strain description Hbegf, heparin-binding EGF like growth factor is a member of the EGF family of growth factor. This protein binds to and activates the EGF receptor. Homozygous mutant mice exhibit grossly enlarged cardiac valves and ventricular chambers. Most homozygous mice died in the first postnatal week. LacZ gene is expressed under the native HB-EGF promoter to examine the expression pattern of the HB-EGF histologically.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Hbegf  
Symbol name heparin-binding epidermal growth factor-like growth factor  
Chromosome 18  
Common name No Data  
Symbol description No Data  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 18  
Common name No Data  
Symbol description E. coli beta galactosidase  
 3 Symbol loxP  
Symbol name phage P1 loxP  
Chromosome 18  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 18  
Common name neo; neomycin;  
Symbol description No Data  
References Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6. Epub 2003 Mar 5.  
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.
Research applications Cardiovascular Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC.  
Additional information
 1 Lab HP (Japanese)  
 2 Mouse of the Month Apr 2006  
 3 Genotyping protocol <PCR>  
Depositor Mekada, Eisuke (Osaka University)  Mekada, Eisuke 
Strain Status /
(Expected delivery)

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