Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01458  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6.129-Dpt<tm1Hsh>/NakaRbrc  
Former Common name Dermatopontin KO mice  
H-2 Haplotype No Data  
Donor strain (129X1/SvJ x 129S1/Sv)F1-Kitl<+>  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Hroshi Shinkai, Chiba University at 2002. A pgk-neo was transfered into ES cells to relpace exon 1 of Dpt gene.  
Strain description Dermatopontin (Dpt) is a collagen-associated protein, is widely distributed in extracellular matrix. Homozygote mutant mice not exhibit any obvious anatomical abnormality, but the skin elasticity was increased. This strain is useful for study of the mechanism and the process of collagen fibrillogenesis.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
Homozygote mutant mice are fertile.  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Dpt  
Symbol name Dermatopontin  
Chromosome 1  
Common name 1810032B19Rik, 5033416F05Rik, early quiescence protein-1, EQ-1  
Symbol description No Data  
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 1  
Common name neo; neomycin;  
Symbol description No Data  
References J Invest Dermatol. 2002 Sep;119(3):678-83.  
Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis.
Research applications Cell Biology Research,
Dermatology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Invest. Dermatol., 119, 678-683 (2002).  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Nakayama, Toshinori (Graduate School of Medicine and School of Medicine, Chiba University)  Nakayama, Toshinori 
Strain Status /
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