Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01474  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6.129-Fas<tm1Osa>/OsaRbrc  
Former Common name B6 Fas-KO  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Drs. Masashi Adachi and Shigekazu Nagata at Osaka University Medical School in 1995.  
Strain description Fas is a cell surface receptor belonging to the tumor necrosis factor receptor superfamily which transduces apoptotic signals in many cell types. Fas deficient mutant mice show lymphoma and autoimmune disorders. In a few month after birth, the mice develop lymphadenoma and splenomegaly by an accumulation of abnormal polyclonal T cells with the CD4-CD8- double negative.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6NCrlCrlj)
Homozygous mutant mice show lymphoma and autoimmune disorders. 50% dead at about 5 months of age.  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Fas  
Symbol name Fas (TNF receptor superfamily member)  
Chromosome 19  
Common name APO-1, CD95, TNFR6, Tnfrsf6  
Symbol description No Data  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 19  
Common name No Data  
Symbol description E. coli beta galactosidase  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 3 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 19  
Common name neo; neomycin;  
Symbol description No Data  
References Nat Genet. 1995 Nov;11(3):294-300.  
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.
Research applications Immunology and Inflammation Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Genetics, 11, 294-300 (1995).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose.
The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Nagata, Shigekazu (Graduate School of Medicine, Kyoto University)  Nagata, Shigekazu 
Strain Status /
Availability
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