Strain Data Sheet
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Data update: May 20, 2019
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RBRC No. RBRC01492  
Type TransgeneCartagena  
Species Mus musculus  
Strain name B6.Cg-Tg(DBH-cre)9-9Koba/KobaRbrc  
Former Common name DBH-Cre/9-9  
H-2 Haplotype No Data  
Background strain C57BL/6JJcl  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1998. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J.  
Strain description These transgenic mice express Cre recombinase gene under the control of the human dopamin beta hydroxylase (DBH) gene promoter. This strain can be used to make an inducible knock-out by crossing with the other genetically-engineered mice that have a loxP site-flanked sequence of interest. The recombination occurs in typical noradrenergic and adrenergic cell groups as well as in transient catecholaminergic cell types. Line 6-8 (RBRC01297), Line 9-9 (RBRC01492).  
Colony maintenance Carrier x Noncarrier [C57BL/6JJcl]  
Health Report
Gene Details
Promoter human dopamine beta-hydroxylase (DBH) promoter, rabbit beta-globin intron, rabbit beta-globin poly A, SV40 early gene poly A  
 1 Symbol cre  
Symbol name Phage P1 Cre recombinase  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References J Neurosci Res. 2004 Oct 1;78(1):7-15.  
Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice.
Research applications Cre/loxP system  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Neurosci. Res., 78, 7-15 (2004).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.  
Additional information
 1 Mouse of the Month June 2006  
 2 Lab HP (Japanese)  
 3 Genotyping protocol <PCR>  
Depositor Kobayashi, Kazuto (Fukushima Medical University)  Kobayashi, Kazuto 
Strain Status /
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