Strain Information | |
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Image | |
BRC No. | RBRC01497 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.Cg-Ncdn<tm2.1Afu>/AfuRbrc |
Former Common name | NC<-/-> |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 2004. |
Strain description | Neurochondrin conditional knock-out mice. The neural tissue-specific neurochondrin is disrupted by Cre-loxP system. Neurochondorin is a cytoplasmic protein involve in neurite outgrowth, chondrocyte differentiation, and bone metabolizm. The nervous system specific deficient mice show that the Ncdh gene is a negative regulator to CaMKII (Ca/calmodulin-dependent protein kinase II) and essential for the spatial learning prosess. |
Colony maintenance | |
References | J. Biol. Chem., 280, 20503-20508 (2005). 15790563 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter NcdnNeurochondrin4Ncdn<tm2.1Afu>targeted mutation 2.1, Akiyoshi FukamizumKIAA0607, neurochondrin-1, neurochondrin-2, norbin Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP4loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP site, mouse Neurochondrin genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 21, 20503-20508 (2005). |
Depositor | Akiyoshi Fukamizu (University of Tsukuba) |
Strain Status | Frozen embryos |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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No Data |