Strain Data Sheet
Data update: Jul 19, 2019
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  Mouse Marking
RBRC No. RBRC01670  
Type Inbred  
Species Mus musculus  
Strain name DDD/Sgn  
Former Common name No Data  
H-2 Haplotype No Data  
Background strain DDD  
 1 Appearance No Data  
Genotype No Data  
Strain development According to Tanaka Matsuzawa (1990) "Inbreeding of dd mice maintained at Denken was commenced in 1957 and the resulting inbred strain was named DDD after dd at Denken. The ancestors of dd mice had come from Germany.
Strain description Mammary tumours 8% at 14 months in virgin and 14% at 14 months in force-bred females. Mammary tumour virus carried by the strain is probably of plaque-inducing group found in DD, RIII and BR6 but not in C3H (Matsuzawa et al., 1974., 1974). Develop a high incidence of heritable hydronephrosis, with a higher incidence observed in males and females. This appears to be caused by an abnormally high internal pressure in the renal pelvis leading to incomplete protection against the vesico-urethral reflex (Mannen et al 1991). Host of a very stable, transplantable pregnancy-dependent mammary tumour TPDMT-4 (Matsuzawa and Yamamoto, 1975). Resistant to the development of uterine tumours following treatment with DMBA at 4-weeks of age (cf 3/6) (Tsubura et al, 1993). High incidence of lethality among F1 Dh/+ male mice resulting from a cross between DDD females and DH-Dh/+ males, however, this is not observed in the reciprocal cross (Suto et al, 1996).  
Health Report
Gene Details
Promoter No Data  
 1 Symbol No Data  
Symbol name No Data  
Chromosome No Data  
Common name No Data  
Symbol description No Data  
References Exp Anim. 1996 Jan;45(1):99-101.  
High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male.
Research applications No Data  
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)  
Additional information
 1 No Data  
Depositor Goto, Hideo (National Institute of Agrobiological Sciences)  Goto, Hideo 
Strain Status /
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