Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC01765  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.129S4-Tob1<tm1Tya>/TyaRbrc  
Former Common name tob-gene KO (B6)  
H-2 Haplotype No Data  
ES cell line J1 [129S4/SvJae]  
Background strain C57BL/6  
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Tetsuo Noda at Japanese Foundation for Cancer Research Cancer Institute and Dr. Tadashi Yamamoto at the University of Tokyo in 1997. A PGK-neo cassette was inserted into the cording region of Tob1 gene. C57BL/6J background.  
Strain description Tob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. This strain is useful for elucidating of Tob gene function.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Tob1  
Symbol name transducer of ErbB-2.1  
Chromosome 11  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References Cell. 2000 Dec 22;103(7):1085-97.
Genes Dev. 2003 May 15;17(10):1201-6.  
Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Yamamoto, Tadashi (The Institute of Medical Science, The University of Tokyo)  Yamamoto, Tadashi 
Strain Status /
(Expected delivery)

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