Strain Data Sheet
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Data update: Jun 20, 2019
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RBRC No. RBRC01766  
Type Targeted Mutation CongenicCartagena  
Species Mus musculus  
Strain name B6.129S4-Tob2<tm1Tya>/TyaRbrc  
Former Common name tob2-gene KO (B6)  
H-2 Haplotype No Data  
Background strain C57BL/6  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo in 1999. LacZ was inserted into Tob2 gene. The mutant mice were backcrossed to C57BL/6J.  
Strain description B6.129S4-Tob2<tm1Tya>. Tob gene is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob2 null mice are viable and appear normal. This strain is useful for elucidating of Tob gene function.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Tob2  
Symbol name transducer of ErbB-2.2  
Chromosome 15  
Common name No Data  
Symbol description No Data  
 2 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 15  
Common name No Data  
Symbol description E. coli beta galactosidase  
References Gene. 2000 Aug 8;253(2):215-20.  
Cloning and characterization of the mouse tob2 gene.
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Yamamoto, Tadashi (The Institute of Medical Science, The University of Tokyo)  Yamamoto, Tadashi 
Strain Status /
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