Strain Data Sheet
Data update: Jul 19, 2019
Health Report   PCR Protocol   Thawing Method
embryos / sperm >
  Mouse Marking
RBRC No. RBRC01767  
Type Targeted Mutation CongenicCartagena   wks
Species Mus musculus  
Strain name B6.129S4-Tob1<tm1Tya> Tob2<tm1Tya>/TyaRbrc  
Former Common name tob and tob2 KO (B6)  
H-2 Haplotype No Data  
Background strain C57BL/6  
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Dr. Tetsuo Noda, Japanese Foundation for Cancer Research Cancer Institute at and Dr. Tadashi Yamamoto at the University of Tokyo. This strain was produced by crossing Tob1 KO mice and Tob2 KO mice.  
Strain description Tob is a member of antiproliferative protein family which is a negative regulator BMP/Smad signaling in osteoblasts. Tob1 null mice are viable and exhibit bone mass due to increased numbers of osteoblasts. While, Tob2 null mice appear normal. This strain is useful for elucidating of Tob gene function.  
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)  
Health Report
Gene Details
Promoter No Data  
 1 Symbol Tob1  
Symbol name transducer of ErbB-2.1  
Chromosome 11  
Common name No Data  
Symbol description No Data  
 2 Symbol Tob2  
Symbol name transducer of ErbB-2.2  
Chromosome 15  
Common name No Data  
Symbol description No Data  
 3 Symbol lacZ  
Symbol name beta-galactosidase (E. coli)  
Chromosome 15  
Common name No Data  
Symbol description E. coli beta galactosidase  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 4 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 11  
Common name neo; neomycin;  
Symbol description No Data  
References No Data  
Research applications No Data  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 Lab HP  
 2 Genotyping protocol <PCR>  
Depositor Yamamoto, Tadashi (The Institute of Medical Science, The University of Tokyo)  Yamamoto, Tadashi 
Strain Status /
(Expected delivery)

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