Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: May 20, 2019
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RBRC No. RBRC01841  
Type TransgeneCartagena   wks
Species Mus musculus  
Strain name B6.Cg-Tg(hGOS2)3Noj  
Former Common name AILE1 TG (ATG3)  
H-2 Haplotype No Data  
Background strain No Data  
Appearance
 1 Appearance black  
Genotype a/a B/B C/C  
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. The transgene was injected into the pronuclei of B6D2F1 fertilized eggs. C57BL/6 and DBA/2 mixed (B6 semicongenic).  
Strain description These transgenic mice express human GOS2 (AILE1) gene that was a gene identified as systemic lupus erythematosus (SLE)-upregutated gene by microarray screening.  
Colony maintenance Carrier x Noncarrier [C57BL/6NCrSlc]  
Health Report No Data  
Gene Details
Promoter CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)  
 1 Symbol AILE1  
Symbol name augmented expression in SLE  
Chromosome UN  
Common name No Data  
Symbol description No Data  
References DNA Res. 2005;12(6):429-39. Epub 2006 Feb 23.
  
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients.
Research applications Mouse Models for Human Disease  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
DNA Res., 12, 429-439 (2005).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 No Data  
Depositor Nojima, Hiroshi (Osaka university)  Nojima, Hiroshi 
Strain Status /
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