Strain Data Sheet

RBRC01896

Strain Information

Image
BRC No.RBRC01896
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6;C3-Mitf<mi-bw>
Former Common nameB6; C3;B6-Mitf-mibw/mibw
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain descriptionThe Mitf, microphthalmia-associated transcription factor plays a critical role in the development of melanocytes, mast cells, osteoclasts and pigmented epithelium. Homozygous mice for the Mitf<mi-bw> mutation display a white coat with black eyes. In this allele, a L1 element was inserted into intron 3. This strain is useful as an animal model for Waardenburg syndrome type 2 (WS2).
Colony maintenanceSibling Mating (Homozygote x Homozygote)
ReferencesHum. Mol. Genet., 8, 1431-1441 (1999). 10400990

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mitfmicrophthalmia-associated transcription factor6Mitf<mi-bw>black eyed whitemi, wh

Ordering Information

Donor DNA
Research applicationDermatology Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 8, 1431-1441 (1999).
DepositorHiroaki Yamamoto (Tohoku University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Additional Info.Mouse of the Month Dec 2006
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.
Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.
Cancer Res 68(20) 8410-8(2008) 18922914