Strain Data Sheet
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Data update: Jul 19, 2019
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RBRC No. RBRC01903  
Type Targeted MutationCartagena  
Species Mus musculus  
Strain name B6;129S2-Lats2<tm1Noj>  
Former Common name Tats2 heterozygous (He) mouse  
H-2 Haplotype No Data  
ES cell line D3 [129S2/SvPas]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2002. D3 ES cells were used. The mutant mice were crossed to C57BL/6.  
Strain description Lats2 gene knockout mice. The first coding exon was replaced with a PGK-neo cassette. Homozygous mutant mice are embryonic lethal.  
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Lats2  
Symbol name large tumor suppressor 2  
Chromosome 14  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 14  
Common name neo; neomycin;  
Symbol description No Data  
References J Biol Chem. 2007 May 3;.  
Lats2 is an essential mitotic regulator required for the coordination of cell division.
Research applications Cell Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J Biol Chem., 282, 19259-19271 (2007).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 No Data  
 2 Genotyping protocol <PCR>  
Depositor Nojima, Hiroshi (Osaka university)  Nojima, Hiroshi 
Strain Status /
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