Strain Data Sheet
ANIMAL SEARCH SYSTEM
Data update: Jul 19, 2019
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RBRC No. RBRC01952  
Type Targeted MutationCartagena   wks
Species Mus musculus  
Strain name B6;129S2-Lats1<tm1Noj>  
Former Common name Lats1 heterozygous (He) mouse  
H-2 Haplotype No Data  
ES cell line D3 [129S2/SvPas]  
Background strain No Data  
Appearance
 1 Appearance No Data  
Genotype No Data  
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. D3 ES cells were used. The mutant mice were crossed to C57BL/6.  
Strain description Lats1 gene knockout mice (deltaN type). Exon 1 containing a translation initiation codon was replaced with a PGK-neo cassette. Homozygous mutant mice are small. Homozygous mutant females cannot nurse pups due to lacking mammae.  
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]  
Health Report No Data  
Gene Details
Promoter No Data  
 1 Symbol Lats1  
Symbol name large tumor suppressor  
Chromosome 10  
Common name No Data  
Symbol description No Data  
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)  
 2 Symbol neo  
Symbol name neomycin resistance gene (E. coli)  
Chromosome 10  
Common name neo; neomycin;  
Symbol description No Data  
References   
Research applications Cell Biology Research  
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J CellSci., 126, 508-520 (2013).
The RECIPIENT agrees to use of this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.  
Additional information
 1 No Data  
Depositor Nojima, Hiroshi (Osaka university)  Nojima, Hiroshi 
Strain Status /
Availability
(Expected delivery)

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