Strain Information | |
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Image | |
BRC No. | RBRC01958 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Ahnak<tm1Jtak> |
Former Common name | Ahnak-KO, Ahnak<tm1Tak> |
H-2 Haplotype | |
ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
Background strain | |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Junji Takeda at Osaka University in 2001. |
Strain description | AHNAK/Desmoyokin is a ubiquitous protein expressed in a variety of cell type, distributes mainly on the cell membranes, suggesting that this gene plays a role in cell-cell adhesion. Homozygous mutant mice are viable and fertile, and show no overt abnormalities. |
Colony maintenance | Backcross to C57BL/6J |
References | J. Invest. Dermatol., 123, 700-707 (2004). 15373775 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter AhnakAHNAK nucleoprotein (demoyokin)19Ahnak<tm1Jtak>targeted mutation 1, Junji Takeda1110004P15Rik, 2310047C17Rik, DY6 Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP19loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP19loxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)19neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo, mouse Ahnak genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J Invest Dermatol, 123, 700-707 (2004).RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. |
Depositor | Junji Takeda (Osaka University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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von Boxberg Y, Soares S, Féréol S, Fodil R, Bartolami S, Taxi J, Tricaud N, Nothias F. Giant scaffolding protein AHNAK1 interacts with β-dystroglycan and controls motility and mechanical properties of Schwann cells. Glia 62(9) 1392-406(2014) 24796807 |